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This issue focuses on tools and enabling technologies for next‑generation computing systems, highlighting AI’s growing impact on software and hardware development, energy-aware operations, and programmability across the compute continuum. It emphasizes European digital autonomy with RISC‑V chiplets (DARE), cloud‑edge‑IoT platforms, and open-source tooling, while showcasing practical advances in GPU tuning, FPGA AI acceleration, DRAM modeling, power optimization, and secure automotive software.