RESCALE revolutionizes software and hardware development by tackling the intricacies of the modern supply chain. Today’s software integrates components from diverse sources in the Software Development Lifecycle (SDLC), accelerating time-to-market but raising security concerns. We aim to establish secure-by-design supply chains, automate evaluations, ensure third-party segments are vulnerability-free, facilitate cybersecurity audits, and construct robust systems. Using a Trusted Bill of Materials (TBOM) mechanism, RESCALE systematically analyzes and extends every layer in a computing system, employing cutting-edge tools and methodologies across the entire supply chain to redefine security standards.